IFTAP

Across TCGA cell cohorts, IFTAP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,789 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IFTAP-associated GO terms across cancer lineages are Protein localization to cilium, Protein neddylation, and tRNA C3-cytosine methylation. Each is linked with IFTAP in more than 10 cancer types. Because this analysis shows association rather than direction, both IFTAP-to-partner and partner-to-IFTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cilium grouped by IFTAP-low versus IFTAP-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFTAP→partner) and Y-score (partner→IFTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein localization to cilium →	+0.072	+2.128	.005	<.001	3	11
PANCREAS	Protein neddylation →	+0.082	+0.854	.006	.005	3	11
LUNG_SCLC	tRNA C3-cytosine methylation →	+0.114	+2.141	.002	<.001	3	10
OVARY	Protein localization to ciliary membrane →	+0.120	+1.119	<.001	<.001	3	10
URINARY_TRACT	Intraciliary anterograde transport →	+0.068	+1.158	.005	.006	2	11
OVARY	Phospholipid translocation →	-0.075	-0.997	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,789 associations by consensus.

Protein localization to cilium by IFTAP expression — LUNG_NSCLC_LUSC

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