IFT88

Across TCGA patient cohorts, IFT88 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT88-associated genes across cancer lineages are 14-3-3_beta, Shc_pY317, and BRD4. Each is linked with IFT88 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT88-to-partner and partner-to-IFT88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IFT88-low versus IFT88-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT88→partner) and Y-score (partner→IFT88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.077	-2.088	.014	.016	3	2
UCEC	Shc_pY317 →	-0.108	-1.137	.023	.041	3	2
UCEC	BRD4 →	+0.195	+1.700	.027	.039	3	2
UCEC	Caspase-7-cleavedD198 →	+0.555	+2.107	.002	.002	3	2
UCEC	C-Raf →	+0.154	+1.440	<.001	.022	3	2
UCEC	Di-Ras3 →	-0.120	-1.584	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

14-3-3_beta by IFT88 expression — UCEC

Explore this box plot interactively →