IFT88

Across TCGA cell cohorts, IFT88 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,700 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IFT88-associated GO terms across cancer lineages are Intraciliary anterograde transport, Protein localization to cilium, and Positive regulation of organelle assembly. Each is linked with IFT88 in more than 15 cancer types. Because this analysis shows association rather than direction, both IFT88-to-partner and partner-to-IFT88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intraciliary anterograde transport grouped by IFT88-low versus IFT88-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT88→partner) and Y-score (partner→IFT88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Intraciliary anterograde transport →	+0.134	+1.102	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to cilium →	+0.073	+1.377	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.066	+1.034	.002	.002	3	13
LUNG_SCLC	Non-motile cilium assembly →	+0.056	+0.661	<.001	<.001	3	13
BONE	Intraciliary transport →	+0.075	+0.821	<.001	<.001	3	13
CNS	Intraciliary transport involved in cilium assembly →	+0.130	+0.670	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,700 associations by consensus.

Intraciliary anterograde transport by IFT88 expression — LUNG_SCLC

Explore this box plot interactively →