IFT88

Across TCGA cell cohorts, IFT88 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible IFT88-associated genes across cancer lineages are CLRN2, ZNF705G, and MS4A4A. Each is linked with IFT88 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT88-to-partner and partner-to-IFT88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN2 grouped by IFT88-low versus IFT88-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT88→partner) and Y-score (partner→IFT88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLRN2 →	+0.026	+5.369	<.001	.004	3	1
BLOOD_Lymphoma	ZNF705G →	+0.006	+4.867	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.157	+3.000	<.001	.006	3	1
LARGE_INTESTINE	KCNK17 →	+0.056	+3.333	.002	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
SKIN	KRTAP4-6 →	+0.049	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CLRN2 by IFT88 expression — SOFT_TISSUE

Explore this box plot interactively →