IFT81

Across TCGA cell cohorts, IFT81 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT81-associated genes across cancer lineages are URAD, SLITRK3, and FRMD1. Each is linked with IFT81 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT81-to-partner and partner-to-IFT81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, URAD grouped by IFT81-low versus IFT81-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT81→partner) and Y-score (partner→IFT81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	URAD →	+0.065	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SLITRK3 →	+0.029	+3.289	<.001	.009	3	1
BLOOD_Leukemia	FRMD1 →	+0.099	+3.847	.001	.004	2	2
BLOOD_Leukemia	OFCC1 →	+0.462	+3.234	<.001	.008	3	1
BLOOD_Leukemia	TRIM49B →	+0.092	+3.289	<.001	.009	3	1
BLOOD_Leukemia	KRTAP5-6 →	+0.205	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

URAD by IFT81 expression — LUNG_SCLC

Explore this box plot interactively →