IFT52

Across TCGA patient cohorts, IFT52 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT52-associated genes across cancer lineages are Notch1, EGFR_pY1068, and A-Raf_pS299. Each is linked with IFT52 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT52-to-partner and partner-to-IFT52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IFT52-low versus IFT52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT52→partner) and Y-score (partner→IFT52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.171	+2.331	.005	.019	3	2
UCEC	EGFR_pY1068 →	-0.216	-2.115	.049	.019	3	1
UCEC	A-Raf_pS299 →	-0.126	-3.000	.015	.036	3	1
UCEC	MEK1 →	+0.432	+2.321	.006	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.221	+2.128	.014	.010	3	1
UCEC	Rab25 →	-0.366	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by IFT52 expression — UCEC

Explore this box plot interactively →