IFT46

Across TCGA patient cohorts, IFT46 mutation is significantly associated with the RNA expression of many other genes, with 2,203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT46-associated genes across cancer lineages are RNA5SP411, MIR30D, and MTND1P6. Each is linked with IFT46 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT46-to-partner and partner-to-IFT46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by IFT46-low versus IFT46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT46→partner) and Y-score (partner→IFT46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.049	+1.978	<.001	.002	3	2
SKCM	MIR30D →	+0.388	+7.816	<.001	.008	3	2
CESC	MTND1P6 →	+0.085	+6.569	<.001	.001	3	2
UCEC	TRAJ24 →	+0.479	+2.040	<.001	.002	3	2
UCEC	TRAJ5 →	+0.516	+1.680	.002	.008	3	2
UCEC	RNA5SP410 →	+0.476	+2.088	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,203 associations by consensus.

RNA5SP411 by IFT46 expression — UCEC

Explore this box plot interactively →