IFT46

Across TCGA patient cohorts, IFT46 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT46-associated genes across cancer lineages are MEK1, Bak, and eEF2. Each is linked with IFT46 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT46-to-partner and partner-to-IFT46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by IFT46-low versus IFT46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT46→partner) and Y-score (partner→IFT46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.361	+3.169	.012	.018	3	2
UCEC	Bak →	+0.219	+1.807	.026	.025	3	2
UCEC	eEF2 →	+0.346	+2.321	.013	.034	3	1
UCEC	EGFR_pY1068 →	-0.266	-2.000	.006	.010	3	1
UCEC	ERK2 →	+0.201	+2.000	.007	.010	3	1
UCEC	GAPDH →	+0.421	+2.459	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by IFT46 expression — UCEC

Explore this box plot interactively →