IFT43

Across TCGA patient cohorts, IFT43 mutation is significantly associated with the RNA expression of many other genes, with 2,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT43-associated genes across cancer lineages are WBP11P3, TUBGCP5, and RNA5SP411. Each is linked with IFT43 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFT43-to-partner and partner-to-IFT43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WBP11P3 grouped by IFT43-low versus IFT43-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT43→partner) and Y-score (partner→IFT43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	WBP11P3 →	+0.065	+3.941	<.001	.003	3	3
UCEC	TUBGCP5 →	+0.483	+2.447	.001	.001	3	2
UCEC	RNA5SP411 →	+1.211	+1.934	<.001	.005	3	2
UCEC	PGAP2 →	+0.577	+3.098	<.001	<.001	3	2
UCEC	EI24 →	+0.450	+2.415	.007	.003	3	2
UCEC	NCAPD3 →	+0.836	+3.708	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,003 associations by consensus.

WBP11P3 by IFT43 expression — BLCA

Explore this box plot interactively →