IFT27

Across TCGA pan-cancer cohorts, IFT27 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IFT27 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IFT27 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IFT27 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where IFT27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.496	0.911	.006	39	view →
HNSC	DFS	Quartile	IV	0.930	0.659	.030	6	view →
UCEC	DFS	Median	All	0.921	0.797	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IFT27–CCRCC (OS)

Open the CCRCC breakdown →