IFT27

Across TCGA patient cohorts, IFT27 mutation is significantly associated with the RNA expression of many other genes, with 729 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT27-associated genes across cancer lineages are YKT6, MRPL18, and SELENOK. Each is linked with IFT27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT27-to-partner and partner-to-IFT27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YKT6 grouped by IFT27-low versus IFT27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT27→partner) and Y-score (partner→IFT27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YKT6 →	+0.474	+2.415	.001	.003	3	2
UCEC	MRPL18 →	+0.328	+2.447	.009	.001	3	2
UCEC	SELENOK →	+0.464	+3.648	<.001	.001	3	2
UCEC	GOT2 →	+0.462	+2.436	.002	.002	3	2
UCEC	DNAJC8 →	+0.379	+2.823	.003	.001	3	2
UCEC	SCLY →	+0.215	+3.256	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 729 associations by consensus.

YKT6 by IFT27 expression — UCEC

Explore this box plot interactively →