IFT27

Across TCGA patient cohorts, IFT27 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT27-associated genes across cancer lineages are EGFR_pY1068, GSK3-a-b, and JNK_pT183_Y185. Each is linked with IFT27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT27-to-partner and partner-to-IFT27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IFT27-low versus IFT27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT27→partner) and Y-score (partner→IFT27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.288	-2.321	.022	.035	3	1
UCEC	GSK3-a-b →	+0.175	+2.321	.010	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.178	-2.308	.035	.036	3	1
UCEC	MEK1 →	+0.504	+3.169	.006	.019	3	1
UCEC	mTOR_pS2448 →	-0.240	-2.986	.001	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.236	+2.335	.022	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by IFT27 expression — UCEC

Explore this box plot interactively →