IFT22

Across TCGA patient cohorts, IFT22 mutation is significantly associated with the RNA expression of many other genes, with 654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT22-associated genes across cancer lineages are RNU1-57P, LCEP1, and OR9Q2. Each is linked with IFT22 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFT22-to-partner and partner-to-IFT22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by IFT22-low versus IFT22-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT22→partner) and Y-score (partner→IFT22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-57P →	+0.537	+5.026	<.001	.009	3	3
STAD	LCEP1 →	+0.266	+5.463	<.001	.005	3	2
COAD	OR9Q2 →	+0.091	+6.721	<.001	<.001	3	2
CESC	YBX1P9 →	+0.074	+5.010	<.001	.009	3	1
CESC	ELAVL4-AS1 →	+0.051	+5.103	.006	.008	3	1
CESC	RNA5SP162 →	+0.680	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 654 associations by consensus.

RNU1-57P by IFT22 expression — STAD

Explore this box plot interactively →