IFT22

Across TCGA patient cohorts, IFT22 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT22-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Myosin-IIa_pS1943. Each is linked with IFT22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT22-to-partner and partner-to-IFT22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IFT22-low versus IFT22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT22→partner) and Y-score (partner→IFT22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.157	-2.973	.002	.035	3	1
UCEC	EGFR_pY1068 →	-0.329	-3.321	.012	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.258	+3.335	.017	.005	3	1
UCEC	Myosin-IIa →	+0.248	+2.818	.014	.035	3	1
UCEC	STAT3_pY705 →	-0.434	-2.999	.001	.035	3	1
UCEC	VHL →	-0.736	-3.000	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by IFT22 expression — UCEC

Explore this box plot interactively →