IFT20

Across TCGA patient cohorts, IFT20 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT20-associated genes across cancer lineages are Ku80, Myosin-IIa_pS1943, and c-Met_pY1235. Each is linked with IFT20 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT20-to-partner and partner-to-IFT20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IFT20-low versus IFT20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT20→partner) and Y-score (partner→IFT20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.391	+2.820	.006	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.258	+2.820	.041	.036	3	1
UCEC	c-Met_pY1235 →	+0.135	+2.817	.002	.036	3	1
UCEC	YAP →	+0.193	+2.817	.035	.036	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Ku80 by IFT20 expression — UCEC

Explore this box plot interactively →