IFT172

Across TCGA patient cohorts, IFT172 mutation is significantly associated with the RNA expression of many other genes, with 6,951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT172-associated genes across cancer lineages are MRPL46, PRMT5, and C1QBP. Each is linked with IFT172 in more than 4 cancer types. Because this analysis shows association rather than direction, both IFT172-to-partner and partner-to-IFT172 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL46 grouped by IFT172-low versus IFT172-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT172→partner) and Y-score (partner→IFT172) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPL46 →	+0.336	+2.635	.001	.005	3	5
UCEC	PRMT5 →	+0.628	+2.403	<.001	<.001	3	4
STAD	C1QBP →	+0.951	+3.354	<.001	.004	3	4
COAD	DCPS →	+0.476	+3.512	<.001	.002	3	4
UCEC	RFC5 →	+0.583	+1.720	<.001	<.001	3	4
UCEC	MESD →	+0.387	+2.279	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,951 associations by consensus.

MRPL46 by IFT172 expression — COAD

Explore this box plot interactively →