Across TCGA patient cohorts, IFT140 mutation is significantly associated with the RNA expression of many other genes, with 3,461 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT140-associated genes across cancer lineages are PBK, ADNP2, and LACTB. Each is linked with IFT140 in more than 3 cancer types. Because this analysis shows association rather than direction, both IFT140-to-partner and partner-to-IFT140 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT140→partner) and Y-score (partner→IFT140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.567	+1.306	.007	.007	3	4
COAD	ADNP2 →	+0.545	+2.197	<.001	.008	3	4
STAD	LACTB →	+0.458	+3.360	<.001	.004	3	4
SKCM	RMDN3 →	+0.391	+3.855	.002	<.001	3	4
SKCM	BNIP3L →	+0.575	+1.854	.003	.005	3	4
COAD	MFAP1 →	+0.381	+2.847	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,461 associations by consensus.

Exploration

IFT140 survival (RNA) · tumor vs normal (RNA) · all IFT140 data types