Across TCGA cell cohorts, IFT140 mutation is significantly associated with the RNA expression of many other genes, with 1,561 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT140-associated genes across cancer lineages are NEK1, FNBP1L, and EDA. Each is linked with IFT140 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFT140-to-partner and partner-to-IFT140 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT140→partner) and Y-score (partner→IFT140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEK1 →	+0.537	+3.169	.001	.006	3	3
LARGE_INTESTINE	FNBP1L →	+0.524	+2.115	.003	.004	3	3
BLOOD_Lymphoma	EDA →	+0.421	+2.655	.001	.007	2	3
LARGE_INTESTINE	BEND3 →	+0.646	+2.584	<.001	.001	3	2
BLOOD_Lymphoma	PLEKHB1 →	+1.150	+3.070	.002	.008	3	2
BLOOD_Lymphoma	CTNS →	+1.104	+3.240	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,561 associations by consensus.

Exploration

IFT140 survival (RNA) · tumor vs normal (RNA) · all IFT140 data types