Across TCGA patient cohorts, IFRD2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFRD2-associated genes across cancer lineages are mTOR_pS2448, c-Kit, and ACC1. Each is linked with IFRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFRD2-to-partner and partner-to-IFRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFRD2→partner) and Y-score (partner→IFRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	+0.229	+2.459	.008	.020	3	1
SKCM	c-Kit →	-0.639	-2.459	.041	.020	3	1
UCEC	ACC1 →	+0.403	+2.000	.013	.032	3	1
UCEC	Notch1 →	+0.198	+2.000	.001	.032	3	1
UCEC	p62 Lck ligand →	+0.415	+3.331	.004	.005	3	1
UCEC	STAT3_pY705 →	-0.462	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

IFRD2 survival (RNA) · tumor vs normal (RNA) · all IFRD2 data types