Across TCGA cell cohorts, IFRD2 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFRD2-associated genes across cancer lineages are C20orf85, NKX2-6, and KRTAP21-2. Each is linked with IFRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFRD2-to-partner and partner-to-IFRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFRD2→partner) and Y-score (partner→IFRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.056	+5.969	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	1
LARGE_INTESTINE	TOMM22 →	+0.574	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

Exploration

IFRD2 survival (RNA) · tumor vs normal (RNA) · all IFRD2 data types