IFNW1

Across TCGA patient cohorts, IFNW1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNW1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Mre11, and Tuberin_pT1462. Each is linked with IFNW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNW1-to-partner and partner-to-IFNW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by IFNW1-low versus IFNW1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNW1→partner) and Y-score (partner→IFNW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.456	+2.179	.041	.034	3	1
UCEC	Mre11 →	-0.127	-3.321	.004	.010	3	1
UCEC	Tuberin_pT1462 →	+0.390	+3.009	.001	.019	3	1
UCEC	Heregulin →	-0.140	-3.321	.030	.010	2	1
UCEC	Tuberin →	+0.335	+2.817	.017	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GSK-3a-b_pS21_S9 by IFNW1 expression — UCEC

Explore this box plot interactively →