IFNLR1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IFNLR1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNLR1-associated genes across cancer lineages are eEF2, INPP4B, and mTOR_pS2448. Each is linked with IFNLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNLR1-to-partner and partner-to-IFNLR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNLR1→partner) and Y-score (partner→IFNLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeEF2 →+0.354+2.321.019.03332
UCECINPP4B →-0.398-3.321.003.00932
UCECmTOR_pS2448 →-0.178-3.446.004.00532
UCECCaspase-7-cleavedD198 →+0.542+2.189.031.03432
UCECCyclin-B1 →+0.879+4.000<.001<.00132
UCECEGFR_pY1068 →-0.229-2.321.031.03431
Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration