IFNL4P1

Across TCGA pan-cancer cohorts, IFNL4P1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IFNL4P1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher IFNL4P1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IFNL4P1 expression acts as an unfavorable survival marker, although some lineages such as CESC and UCEC show a favorable association.

CESC, COAD, and UCEC are the cancer types where IFNL4P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.940	0.598	.001	54	view →
COAD	OS	Tertile	IV	0.123	0.658	.003	36	view →
UCEC	DFS	Median	IV	0.764	0.251	<.001	36	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	36	view →
ESCA	DFS	Quartile	II,III,IV	0.316	0.564	<.001	27	view →
STAD	OS	Median	III,IV	0.646	0.462	.019	24	view →
UCS	OS	Median	III,IV	0.507	0.207	.018	18	view →
UVM	OS	Tertile	All	0.386	0.815	.003	16	view →
LIHC	OS	Tertile	II,III,IV	0.425	0.639	.031	12	view →
SKCM	OS	Tertile	IV	0.167	0.657	.003	9	view →
LUSC	DFS	Tertile	II,III,IV	0.882	0.457	.040	6	view →
OV	OS	Median	All	0.646	0.712	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IFNL4P1–CESC (DFS)

Open the CESC breakdown →