Across TCGA patient cohorts, IFNL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,499 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IFNL3-associated GO terms across cancer lineages are Regulation of ribonuclease activity, Interleukin-27-mediated signaling pathway, and ISG15-protein conjugation. Each is linked with IFNL3 in more than 17 cancer types. Because this analysis shows association rather than direction, both IFNL3-to-partner and partner-to-IFNL3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL3→partner) and Y-score (partner→IFNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Regulation of ribonuclease activity →	+0.100	+0.418	<.001	<.001	3	18
BRCA	Interleukin-27-mediated signaling pathway →	+0.098	+0.393	<.001	<.001	3	18
UCS	ISG15-protein conjugation →	+0.100	+0.582	<.001	<.001	3	17
STAD	Positive regulation of toll-like receptor 9 signaling pathway →	+0.061	+0.335	<.001	<.001	3	17
STAD	DTTP metabolic process →	+0.059	+0.250	<.001	<.001	3	17
ESCA	Regulation by virus of viral protein levels in host cell →	+0.070	+0.325	<.001	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,499 associations by consensus.

Exploration

IFNL3 survival (RNA) · tumor vs normal (RNA) · all IFNL3 data types