Across TCGA patient cohorts, IFNL3 mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNL3-associated genes across cancer lineages are RNY1P1, RBM17P1, and ELOCP20. Each is linked with IFNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNL3-to-partner and partner-to-IFNL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL3→partner) and Y-score (partner→IFNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNY1P1 →	+0.294	+4.970	<.001	.005	3	2
SKCM	RBM17P1 →	+0.046	+4.513	<.001	.009	3	2
SKCM	ELOCP20 →	+0.126	+4.594	.001	.008	3	2
COAD	SNORD116-12 →	+0.715	+5.602	<.001	.004	3	1
COAD	MIR1302-7 →	+0.648	+7.409	<.001	<.001	3	1
COAD	ELOBP3 →	+0.209	+5.790	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

Exploration

IFNL3 survival (RNA) · tumor vs normal (RNA) · all IFNL3 data types