Across TCGA patient cohorts, IFNL3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNL3-associated genes across cancer lineages are ASNS, p62 Lck ligand, and PAI-1. Each is linked with IFNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNL3-to-partner and partner-to-IFNL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL3→partner) and Y-score (partner→IFNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.501	+3.000	.016	.037	2	2
UCEC	p62 Lck ligand →	+0.511	+3.000	.006	.037	2	1
UCEC	PAI-1 →	-0.443	-3.000	.025	.037	2	1
UCEC	VHL →	-1.472	-3.000	<.001	.037	2	1
UCEC	4E-BP1 →	+0.438	+3.000	.005	.037	2	1
UCEC	Cyclin-E2 →	+0.216	+3.000	.026	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

IFNL3 survival (RNA) · tumor vs normal (RNA) · all IFNL3 data types