Across TCGA cell cohorts, IFNL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 499 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible IFNL3-associated GO terms across cancer lineages are Interleukin-27-mediated signaling pathway, MDA-5 signaling pathway, and Negative regulation of type I interferon-mediated signaling pathway. Each is linked with IFNL3 in more than 7 cancer types. Because this analysis shows association rather than direction, both IFNL3-to-partner and partner-to-IFNL3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL3→partner) and Y-score (partner→IFNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Interleukin-27-mediated signaling pathway →	+0.266	+0.163	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.262	+0.149	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of type I interferon-mediated signaling pathway →	+0.169	+0.221	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromatin binding →	+0.188	+0.170	<.001	.003	2	8
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.079	+0.172	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of defense response to virus →	+0.077	+0.155	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

Exploration

IFNL3 survival (RNA) · tumor vs normal (RNA) · all IFNL3 data types