Across TCGA cell cohorts, IFNL3 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFNL3-associated genes across cancer lineages are Doxorubicin, Bleomycin (10 uM), and AZD4877. Each is linked with IFNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNL3-to-partner and partner-to-IFNL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL3→partner) and Y-score (partner→IFNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Doxorubicin →	+0.721	+3.064	.002	.009	3	1
LARGE_INTESTINE	Bleomycin (10 uM) →	+0.638	+3.064	.026	.009	3	1
LARGE_INTESTINE	AZD4877 →	+0.771	+3.064	.014	.009	3	1
LARGE_INTESTINE	PARP_0108 →	+0.752	+3.064	.008	.009	2	2
LARGE_INTESTINE	LCL161 →	+0.397	+2.672	.006	.039	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.734	+2.807	.012	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

IFNL3 survival (RNA) · tumor vs normal (RNA) · all IFNL3 data types