Across TCGA pan-cancer cohorts, IFNL2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IFNL2 data layer compared with 20 for mass-spec protein.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IFNL2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IFNL2 expression acts as an unfavorable survival marker.
LUSC, PAAD, and CESC are the cancer types where IFNL2 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.