IFNL1

Across TCGA pan-cancer cohorts, IFNL1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IFNL1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher IFNL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IFNL1 expression acts as an unfavorable survival marker.

CESC and COAD are the cancer types where IFNL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.261	0.798	.006	12	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IFNL1–CESC (OS)

Open the CESC breakdown →