IFNL1

Across TCGA patient cohorts, IFNL1 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IFNL1-associated genes across cancer lineages are RNA5SP411, H3P9, and RNU2-47P. Each is linked with IFNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNL1-to-partner and partner-to-IFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by IFNL1-low versus IFNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL1→partner) and Y-score (partner→IFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+2.524	+4.393	<.001	.002	3	2
UCEC	H3P9 →	+0.764	+3.863	<.001	.008	3	2
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	2
COAD	EEF1A1P39 →	+0.295	+4.324	.002	.007	3	1
COAD	CAPZA1P4 →	+0.196	+5.868	<.001	<.001	3	1
COAD	GAPDHP41 →	+0.206	+4.266	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RNA5SP411 by IFNL1 expression — UCEC

Explore this box plot interactively →