IFNL1

Across TCGA cell cohorts, IFNL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,282 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible IFNL1-associated GO terms across cancer lineages are MDA-5 signaling pathway, Antiviral innate immune response, and Negative regulation of viral genome replication. Each is linked with IFNL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IFNL1-to-partner and partner-to-IFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDA-5 signaling pathway grouped by IFNL1-low versus IFNL1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL1→partner) and Y-score (partner→IFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.300	+0.459	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Antiviral innate immune response →	+0.097	+0.565	<.001	<.001	3	12
CNS	Negative regulation of viral genome replication →	+0.199	+0.091	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.155	+0.511	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.089	+0.516	<.001	<.001	3	12
BREAST	Regulation of viral life cycle →	+0.113	+0.455	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,282 associations by consensus.

MDA-5 signaling pathway by IFNL1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →