IFNL1

Across TCGA cell cohorts, IFNL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible IFNL1-associated genes across cancer lineages are ACSM6, TRPC5OS, and HBG1. Each is linked with IFNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNL1-to-partner and partner-to-IFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by IFNL1-low versus IFNL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL1→partner) and Y-score (partner→IFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.020	+4.169	.004	.007	3	1
LARGE_INTESTINE	TRPC5OS →	+0.035	+3.854	<.001	.006	3	1
LARGE_INTESTINE	HBG1 →	+0.123	+4.054	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
LUNG_SCLC	CCL7 →	+0.414	+4.044	<.001	.009	3	1
LUNG_SCLC	SMCP →	+0.047	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ACSM6 by IFNL1 expression — LARGE_INTESTINE

Explore this box plot interactively →