IFNGR2

Across TCGA patient cohorts, IFNGR2 mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNGR2-associated genes across cancer lineages are MIR425, OR9A1P, and RPS12P15. Each is linked with IFNGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNGR2-to-partner and partner-to-IFNGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR425 grouped by IFNGR2-low versus IFNGR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNGR2→partner) and Y-score (partner→IFNGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR425 →	+0.382	+2.399	.001	.001	3	2
SKCM	OR9A1P →	+0.046	+3.953	.003	.005	3	1
SKCM	RPS12P15 →	+0.101	+3.661	.002	.009	3	1
SKCM	RN7SL831P →	+0.120	+5.634	<.001	.001	3	1
SKCM	LINC02500 →	+0.085	+5.039	<.001	.003	3	1
UCEC	SNRPGP17 →	+0.257	+2.048	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

MIR425 by IFNGR2 expression — UCEC

Explore this box plot interactively →