IFNGR2

Across TCGA patient cohorts, IFNGR2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNGR2-associated genes across cancer lineages are Notch1, p27_pT157, and VHL. Each is linked with IFNGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNGR2-to-partner and partner-to-IFNGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IFNGR2-low versus IFNGR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNGR2→partner) and Y-score (partner→IFNGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.130	+2.331	.040	.019	3	1
UCEC	p27_pT157 →	-0.064	-2.282	.014	.034	3	1
UCEC	VHL →	-1.339	-3.807	<.001	<.001	3	1
UCEC	Caspase-8 →	-0.229	-3.558	.043	.002	3	1
UCEC	JNK2 →	+0.255	+2.700	.004	.006	2	1
UCEC	MEK1 →	+0.587	+3.807	<.001	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by IFNGR2 expression — UCEC

Explore this box plot interactively →