IFNGR2

Across TCGA cell cohorts, IFNGR2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFNGR2-associated genes across cancer lineages are OR7G2, REG1B, and KRTAP4-6. Each is linked with IFNGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNGR2-to-partner and partner-to-IFNGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7G2 grouped by IFNGR2-low versus IFNGR2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNGR2→partner) and Y-score (partner→IFNGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR7G2 →	+0.032	+5.201	<.001	.006	3	1
BLOOD_Leukemia	REG1B →	+0.132	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP4-6 →	+0.052	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OPN1MW →	+0.062	+5.539	<.001	.003	3	1
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	OR7G3 →	+0.063	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR7G2 by IFNGR2 expression — BLOOD_Leukemia

Explore this box plot interactively →