IFNG

Across TCGA patient cohorts, IFNG RNA expression is significantly associated with the protein abundance of many other proteins, with 14,362 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IFNG-associated proteins across cancer lineages are RCSD1, SASH3, and CASP1. Each is linked with IFNG in more than 9 cancer types. Because this analysis shows association rather than direction, both IFNG-to-partner and partner-to-IFNG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFNG versus RCSD1 in HNSC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNG→partner) and Y-score (partner→IFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.654	+1.079	<.001	<.001	3	10
OV	SASH3 →	+0.536	+0.813	<.001	<.001	3	10
OV	CASP1 →	+0.571	+0.778	<.001	<.001	3	10
BRCA	CORO1A →	+0.646	+1.201	<.001	<.001	3	10
LSCC	DOCK10 →	+0.514	+1.145	<.001	<.001	3	10
BRCA	GBP4 →	+0.764	+1.159	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,362 associations by consensus.

IFNG vs RCSD1 — HNSC

Explore this scatter interactively →