IFNG

Across TCGA cell cohorts, IFNG mutation is significantly associated with the mutation status of many other genes, with 509 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFNG-associated genes across cancer lineages are KLHL13, TDP2, and PRDM5. Each is linked with IFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNG-to-partner and partner-to-IFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL13 grouped by IFNG-low versus IFNG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNG→partner) and Y-score (partner→IFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL13 →	+2.422	+4.050	.004	.004	1	2
LARGE_INTESTINE	TDP2 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	PRDM5 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	CRABP2 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	CSRNP1 →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	TAAR8 →	+3.329	+3.799	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

KLHL13 by IFNG expression — LARGE_INTESTINE

Explore this box plot interactively →