IFNG-AS1

Across TCGA pan-cancer cohorts, IFNG-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IFNG-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IFNG-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IFNG-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, OV, and SKCM are the cancer types where IFNG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.712	0.556	<.001	116	view →
OV	OS	Tertile	III,IV	0.427	0.262	<.001	94	view →
SKCM	DFS	Tertile	All	0.691	0.553	<.001	89	view →
LUAD	OS	Quartile	II,III,IV	0.792	0.422	<.001	70	view →
BRCA	OS	Median	All	0.974	0.951	.002	63	view →
CESC	DFS	Tertile	All	0.857	0.672	<.001	60	view →
LGG	DFS	Tertile	All	0.679	0.859	<.001	26	view →
CHOL	DFS	Median	All	0.711	0.168	<.001	21	view →
ESCA	DFS	Median	III,IV	0.412	0.222	.012	20	view →
DLBC	DFS	Tertile	III,IV	1.000	0.318	.016	17	view →
LIHC	DFS	Tertile	III,IV	0.596	0.249	.005	15	view →
UVM	DFS	Quartile	All	0.282	0.790	<.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IFNG-AS1–HNSC (DFS)

Open the HNSC breakdown →