IFNB1

Across TCGA patient cohorts, IFNB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,747 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IFNB1-associated GO terms across cancer lineages are Regulation of viral genome replication, Negative regulation of viral process, and Negative regulation of type I interferon-mediated signaling pathway. Each is linked with IFNB1 in more than 23 cancer types. Because this analysis shows association rather than direction, both IFNB1-to-partner and partner-to-IFNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral genome replication grouped by IFNB1-low versus IFNB1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNB1→partner) and Y-score (partner→IFNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of viral genome replication →	+0.063	+0.102	<.001	<.001	3	24
STAD	Negative regulation of viral process →	+0.059	+0.071	<.001	<.001	3	23
ESCA	Negative regulation of type I interferon-mediated signaling pathway →	+0.070	+0.140	<.001	<.001	3	23
UCS	Regulation of ribonuclease activity →	+0.143	+0.410	<.001	<.001	3	23
UCS	Interleukin-27-mediated signaling pathway →	+0.172	+0.441	<.001	<.001	2	24
UCS	Negative regulation of viral genome replication →	+0.077	+0.360	<.001	<.001	2	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,747 associations by consensus.

Regulation of viral genome replication by IFNB1 expression — ESCA

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