IFNB1

Across TCGA patient cohorts, IFNB1 mutation is significantly associated with the RNA expression of many other genes, with 1,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNB1-associated genes across cancer lineages are PLPPR2, TRIM16L, and ZNF330. Each is linked with IFNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNB1-to-partner and partner-to-IFNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLPPR2 grouped by IFNB1-low versus IFNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNB1→partner) and Y-score (partner→IFNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLPPR2 →	+0.875	+2.818	<.001	.001	3	2
UCEC	TRIM16L →	+1.092	+2.601	<.001	.006	3	2
UCEC	ZNF330 →	+0.521	+3.928	.001	<.001	3	2
UCEC	PKMYT1 →	+0.828	+3.917	.001	<.001	3	2
UCEC	SEMA4F →	+0.498	+2.807	.009	.003	3	2
UCEC	SPRY2 →	+1.022	+3.329	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,138 associations by consensus.

PLPPR2 by IFNB1 expression — UCEC

Explore this box plot interactively →