IFNB1

Across TCGA cell cohorts, IFNB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 835 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFNB1-associated GO terms across cancer lineages are MDA-5 signaling pathway, Interleukin-27-mediated signaling pathway, and Antiviral innate immune response. Each is linked with IFNB1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IFNB1-to-partner and partner-to-IFNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDA-5 signaling pathway grouped by IFNB1-low versus IFNB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNB1→partner) and Y-score (partner→IFNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.286	+0.269	.001	.003	3	13
CNS	Interleukin-27-mediated signaling pathway →	+0.420	+0.155	<.001	.003	3	11
CNS	Antiviral innate immune response →	+0.061	+0.123	<.001	.002	3	11
BREAST	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.143	+0.101	<.001	.008	3	10
CNS	Negative regulation of viral genome replication →	+0.181	+0.122	<.001	.002	3	10
BREAST	Negative regulation of viral process →	+0.151	+0.183	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

MDA-5 signaling pathway by IFNB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →