IFNAR2

Across TCGA cell cohorts, IFNAR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,265 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFNAR2-associated GO terms across cancer lineages are Type III interferon-mediated signaling pathway, Cellular response to type III interferon, and Interleukin-10-mediated signaling pathway. Each is linked with IFNAR2 in more than 13 cancer types. Because this analysis shows association rather than direction, both IFNAR2-to-partner and partner-to-IFNAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Type III interferon-mediated signaling pathway grouped by IFNAR2-low versus IFNAR2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR2→partner) and Y-score (partner→IFNAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Type III interferon-mediated signaling pathway →	+0.258	+1.083	<.001	.001	3	14
URINARY_TRACT	Cellular response to type III interferon →	+0.258	+1.083	<.001	.001	3	14
LUNG_NSCLC_LUSC	Interleukin-10-mediated signaling pathway →	+0.217	+0.904	.001	.005	3	12
LIVER	Cellular response to virus →	+0.136	+1.495	.001	.003	3	12
LUNG_NSCLC_LUSC	Response to type III interferon →	+0.218	+1.011	.001	.007	3	11
UPPER_AERODIGESTIVE_TRACT	Response to interferon-beta →	+0.120	+0.639	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,265 associations by consensus.

Type III interferon-mediated signaling pathway by IFNAR2 expression — URINARY_TRACT

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