IFNAR2

Across TCGA cell cohorts, IFNAR2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IFNAR2-associated genes across cancer lineages are OR1L3, CCDC60, and PNLIPRP1. Each is linked with IFNAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNAR2-to-partner and partner-to-IFNAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by IFNAR2-low versus IFNAR2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR2→partner) and Y-score (partner→IFNAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L3 →	+0.047	+4.029	<.001	.009	3	1
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
OVARY	ARMH2 →	+0.039	+4.228	<.001	.006	3	1
BLOOD_Leukemia	GSC →	+0.887	+2.948	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR1L3 by IFNAR2 expression — OVARY

Explore this box plot interactively →