IFNAR1

Across TCGA patient cohorts, IFNAR1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,998 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IFNAR1-associated genes across cancer lineages are GPR89A, UBA2, and MCM8. Each is linked with IFNAR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNAR1-to-partner and partner-to-IFNAR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFNAR1 versus GPR89A in LSCC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR1→partner) and Y-score (partner→IFNAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPR89A →	-0.636	-0.413	<.001	<.001	3	3
LSCC	UBA2 →	-0.641	-0.298	<.001	<.001	3	3
LSCC	MCM8 →	-0.991	-0.396	<.001	<.001	3	3
LSCC	SKP2 →	-0.609	-0.252	.006	.006	3	3
LSCC	RFWD3 →	-0.705	-0.384	<.001	<.001	3	3
LSCC	KLRG1 →	+0.895	+0.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,998 associations by consensus.

IFNAR1 vs GPR89A — LSCC

Explore this scatter interactively →