IFNAR1

Across TCGA patient cohorts, IFNAR1 mutation is significantly associated with the RNA expression of many other genes, with 674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNAR1-associated genes across cancer lineages are LCEP1, RNU6-270P, and RNU6-522P. Each is linked with IFNAR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNAR1-to-partner and partner-to-IFNAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCEP1 grouped by IFNAR1-low versus IFNAR1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR1→partner) and Y-score (partner→IFNAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	LCEP1 →	+0.266	+5.463	<.001	.005	3	3
LIHC	RNU6-270P →	+0.445	+5.758	<.001	.003	3	2
LIHC	RNU6-522P →	+0.335	+7.169	<.001	<.001	3	2
LIHC	RPS11P1 →	+0.082	+5.544	.003	.004	3	2
LIHC	RN7SL100P →	+0.134	+6.149	<.001	.002	3	2
STAD	RNA5SP181 →	+0.475	+5.274	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 674 associations by consensus.

LCEP1 by IFNAR1 expression — STAD

Explore this box plot interactively →