IFNAR1

Across TCGA patient cohorts, IFNAR1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNAR1-associated genes across cancer lineages are Notch1, p27_pT198, and A-Raf_pS299. Each is linked with IFNAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNAR1-to-partner and partner-to-IFNAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IFNAR1-low versus IFNAR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR1→partner) and Y-score (partner→IFNAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.194	+2.472	<.001	.010	3	2
UCEC	p27_pT198 →	+0.097	+2.321	.028	.006	3	2
UCEC	A-Raf_pS299 →	-0.105	-3.000	.032	.036	3	1
UCEC	MSH2 →	-0.202	-2.295	.033	.033	3	1
UCEC	mTOR_pS2448 →	-0.154	-3.439	.012	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.457	-2.986	.013	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by IFNAR1 expression — UCEC

Explore this box plot interactively →