IFNAR1

Across TCGA cell cohorts, IFNAR1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IFNAR1-associated genes across cancer lineages are KLHL40, SMIM23, and KRTAP21-2. Each is linked with IFNAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNAR1-to-partner and partner-to-IFNAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by IFNAR1-low versus IFNAR1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNAR1→partner) and Y-score (partner→IFNAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SMIM23 →	+0.061	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP21-2 →	+0.070	+5.209	.003	.005	3	1
BLOOD_Lymphoma	USP17L4 →	+0.013	+5.209	<.001	.005	3	1
LARGE_INTESTINE	SEL1L2 →	+0.060	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KLHL40 by IFNAR1 expression — BLOOD_Lymphoma

Explore this box plot interactively →