IFNA6

Across TCGA pan-cancer cohorts, IFNA6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IFNA6 data layer compared with 9 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IFNA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFNA6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where IFNA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.669	0.894	.004	27	view →
UCEC	DFS	Tertile	All	0.984	0.776	.003	20	view →
LSCC	OS	Tertile	III,IV	0.613	0.986	.034	4	view →
LUAD	OS	Median	II,III,IV	0.998	0.864	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IFNA6–HNSC (DFS)

Open the HNSC breakdown →