IFNA6

Across TCGA patient cohorts, IFNA6 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IFNA6-associated genes across cancer lineages are AQP7P3, H2BC2P, and CCK. Each is linked with IFNA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNA6-to-partner and partner-to-IFNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P3 grouped by IFNA6-low versus IFNA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA6→partner) and Y-score (partner→IFNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P3 →	+0.025	+4.260	.005	.007	3	1
SKCM	H2BC2P →	+0.080	+4.469	<.001	.006	3	1
SKCM	CCK →	+0.328	+3.690	<.001	.007	3	1
SKCM	BSPH1 →	+0.722	+3.526	<.001	.005	3	1
SKCM	RNA5SP432 →	+0.607	+4.533	<.001	<.001	3	1
SKCM	RNU2-37P →	+0.482	+4.216	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

AQP7P3 by IFNA6 expression — UCEC

Explore this box plot interactively →